Advancing the future of Precision Neurology

Building a deeper understanding of brain disease through biological insight and scientific collaboration.

header graphic of brain image line drawing with networking dots connected throughout the image. faint line waves stretch across the screen behind it with a cluster of networking paths and dots to the left and the right of the brain image.

Our Purpose

Brain disorders remain among the most complex challenges in medicine.

Advances in biomarker science, computational biology, and neuroscience are redefining what is possible.

At Circular Genomics, we believe a deeper understanding of disease biology is essential to advancing precision neurology. Through circular RNA, we are helping shape a future of earlier biological insight, more precise interventions, and improved outcomes for people affected by neurological disease.

01

Brain Disease
Biology

The foundation of everything we do.

Understanding the complex biological processes that drive neurological disease.

02

Brain-Derived circRNA

A new layer of biological insight.

Stable molecular signals providing visibility into multiple interconnected biological pathways.

03

CircPathTM Platform

Transforming signals into molecular intelligence.

A proprietary platform that translates circRNA signals into actionable biological insights.

04

Research Applications

Advancing neuroscience research.

Research tools designed to support biomarker discovery, patient stratification, therapeutic development, and precision neurology.

Message from CEO

"Our innovation drives a movement"

Our innovation drives a movement toward a future where brain disorders are measurable, manageable, and treatable —empowering patients and families to lead fuller lives, which is the core of our vision.

Circular Genomics was founded on a breakthrough discovery: the direct link between disease and a new class of brain-derived circular RNA biomarkers. This seminal finding isn't just our origin story; it's the cornerstone of our mission to revolutionize the future of neurological and psychiatric treatment with cutting-edge biomarkers for personalized care.

Moving beyond today's diagnostic barriers, we harness the power of brain-derived circular RNA biomarkers, providing clinicians with a real-time view of brain disease via simple blood tests. This means more accurate detection of the disease pathology, leading to potentially faster and more informed treatment selection decisions for several neurological and psychiatric conditions. Our innovation drives a movement toward a future where brain disorders are measurable, manageable, and treatable—empowering patients and families to lead fuller lives, which is the core of our vision.  

Our team is passionate and already making a difference for patients and providers. As shown in clinical studies, MindLight, our first commercially available circular RNA biomarker diagnostic, predicts SSRI response in patients suffering from major depressive disorder (MDD) with a diagnostic accuracy of close to 80%. We are actively developing

Paul Sargeant, PhD
President and Chief Executive Officer

Leadership & Advisors

The Team Behind Circular Genomics

he Circular Genomics team brings together expertise across neuroscience, genomics, diagnostics, clinical research, and biotechnology commercialization.

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Paul Sargeant, President and Chief Executive Officer, Member of Board of Directors
Paul
Sargeant
Executive Team
Board of Directors
PhD
President and Chief Executive Officer, Member of Board of Directors
Carlos Cruchaga, PhD, Professor of Psychiatry and Neurology, Washington University School of Medicine
Carlos
Cruchaga
Scientific Advisory Board
PhD
Professor of Psychiatry and Neurology, Washington University School of Medicine
Andrew Lechleiter, Chief Executive Officer
Andrew
Lechleiter
Commercial Advisory Board
Poplar Grove Investors, LLC
Chief Executive Officer
Nikolaos Mellios, MD, PhD, Chief Scientific Officer, Member of Board of Directors Cofounder
Nikolaos
Mellios
Executive Team
Board of Directors
MD, PhD
Chief Scientific Officer, Member of Board of Directors Cofounder
Timothy Hohman, Professor, Neurology Vanderbilt University Memory and Alzheimer's Center
Timothy
Hohman
Scientific Advisory Board
PhD
Professor, Neurology Vanderbilt University Memory and Alzheimer's Center
Laura Viaches, President & Founder, Endeavor Pharma Solutions
Laura
Viaches
Commercial Advisory Board
President & Founder, Endeavor Pharma Solutions
Sami Shihabi, Chief Commercial Officer
Sami
Shihabi
Executive Team
Chief Commercial Officer
Dave Blivin, Managing Director, Cottonwood Technology Fund
Dave
Blivin
Board of Directors
Managing Director, Cottonwood Technology Fund
 Henrik Zetterberg, Professor of Neurochemistry at the University of Gothenburg, Sweden, University of Wisconsin-Madison, and University College London (UCL)
Henrik
Zetterberg
Scientific Advisory Board
MD, PhD
Professor of Neurochemistry at the University of Gothenburg, Sweden, University of Wisconsin-Madison, and University College London (UCL)
Jim R. Grana, Vice President, Blue Cross Blue Shield of South Carolina
Jim
Grana
Commercial Advisory Board
PhD
Vice President, Blue Cross Blue Shield of South Carolina
Greg Decker, Chief Financial Officer
Greg
Decker
Executive Team
Chief Financial Officer
Ron Rocca, President & Chief Executive Officer, Mindera Health
Ron
Rocca
Board of Directors
President & Chief Executive Officer, Mindera Health
Michael Weiner, Emeritus Professor in Residence, Neurology/Radiology UCSF – Founder of Brain Health Registry - lead PI at ADNI
Michael
Weiner
Scientific Advisory Board
MD
Emeritus Professor in Residence, Neurology/Radiology UCSF – Founder of Brain Health Registry - lead PI at ADNI
Melissa Reilly, Chief Strategy Officer, Evernorth Health Services (former)
Melissa
Reilly
Commercial Advisory Board
JD, MBA
Chief Strategy Officer, Evernorth Health Services (former)
Joe Cook, III, Managing Director, Mountain Group Partners
Joe
Cook, III
Board of Directors
Managing Director, Mountain Group Partners
 Phyllis Barkman Ferrell, Alzheimer's Disease Strategic Advisor, Former Global Head of External Engagement for Alzheimer’s disease at Eli Lilly & Company
Phyllis
Barkman Ferrell
Scientific Advisory Board
MBA, DrPH
Alzheimer's Disease Strategic Advisor, Former Global Head of External Engagement for Alzheimer’s disease at Eli Lilly & Company
Waneta Tuttle, Managing Director, Tramway Venture Partners
Waneta
Tuttle
Board of Directors
PhD
Managing Director, Tramway Venture Partners
Eleni Tzavara, Research Director of Translational Psychopharmacology, Centre National de la Recherche Scientifique
Eleni
Tzavara
Scientific Advisory Board
MD, PhD
Research Director of Translational Psychopharmacology, Centre National de la Recherche Scientifique
Michael Ackermann, Cofounder, Board Member and CBO, Arrivo Bioventures
Michael
Ackermann
Scientific Advisory Board
PhD, MBA
Cofounder, Board Member and CBO, Arrivo Bioventures
Madhukar Trivedi, Chief of the Division of Mood Disorders and Director of the Center for Depression Research and Clinical Care, UT Southwestern Medical Center ​ Professor of Psychiatry, UT Southwestern Medical School
Madhukar
Trivedi
Scientific Advisory Board
MD
Chief of the Division of Mood Disorders and Director of the Center for Depression Research and Clinical Care, UT Southwestern Medical Center ​ Professor of Psychiatry, UT Southwestern Medical School
Roy Perlis, Director, Center of Experimental Drugs & Diagnostics, Massachusetts General Hospital ​ Professor of Psychiatry, Harvard Medical School
Roy
Perlis
Scientific Advisory Board
MD
Director, Center of Experimental Drugs & Diagnostics, Massachusetts General Hospital ​ Professor of Psychiatry, Harvard Medical School

Help Advance the Future of Brain Health

We’re building a team of scientists, innovators, and industry leaders committed to transforming biological signals into molecular intelligence.