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Publications & Resources

August 21, 2026

Blood-based circular RNAs emerge as a breakthrough early diagnostic tool for Alzheimer’s disease

For decades, early detection of Alzheimer’s disease (AD) has remained one of the most intractable challenges in neurodegenerative medicine. Clinical symptoms of dementia typically emerge only after...

August 11, 2026

Circular RNAs outperform established Alzheimer disease biomarkers

Circular RNAs in the blood could be used as a highly sensitive biomarker for Alzheimer disease (AD), according to new research published in Nature Medicine.

Early detection of Alzheimer’s disease with circular RNA from blood

Early diagnosis of Alzheimer’s disease is important to ensure timely and accurate treatment. We show that a blood-based circular RNA signature can accurately detect Alzheimer’s disease as well as, or

Blood-based circular RNAs for early diagnosis of Alzheimer's disease

Blood-Based Circular RNA Biomarkers Outperform Gold-Standard Tests, Enable Preclinical Risk Stratification Years Before Symptom Onset, and Open New Era in Precision Neurology

The history and function of a circular RNA

In 2024, the Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNAs (miRNAs), acknowledging their important role as post-transcriptional regu

February 11, 2026

Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs

Circular RNAs are backspliced, closed-loop RNAs previously believed to be noncoding by-products

September 15, 2025

The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in the mouse visual cortex

Circular RNAs (circRNAs) are closed-loop, single-stranded RNAs particularly enriched in the brain.

A brain-enriched circRNA bloodbiomarker can predict response to SSRI antidepressants

Major Depressive Disorder (MDD) is a debilitating psychiatric disorder that currently affects more than 20% of the adult US population

January 12, 2024

Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade

There are currently only very few efficacious drug treatments for SCZ and BD, none of which can significantly ameliorate cognitive symptoms.

February 17, 2023

Prenatal alcohol exposure results in brain region and sex-specific changes in circHomer1 expression in adult mouse brain

Circular RNAs (circRNAs) are a novel category of covalently-closed non-coding RNAs mainly derived from the back-splicing of exons or introns of protein-coding genes.

Knockdown of circHomer1 in the orbitofrontal cortex results in differential encoding of salient stimuli

CircHomer1 is an activity-dependent circular RNA (circRNA) isoform produced from back-splicing of the Homer1 transcript.

January 18, 2022

A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning

Although circular RNAs (circRNAs) are enriched in the brain, their relevance for brain function and psychiatric disorders is poorly understood.

January 27, 2020

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition

Although circular RNAs (circRNAs) are enriched in the mammalian brain, very little is known about their potential involvement in brain function and psychiatric disease.

October 7, 2019

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center

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