CircRNAs provide unique molecular insight into brain function and neurolgoical disease.
CircRNAs are highly enriched in the brain relative to other tissues.
These circRNAs are associated with biological processes involved in neuronal function, cognition, and synaptic communication.
This unique brain enrichment makes circRNA valuable for investigating the biological processes underlying neurological diseases.
Neurological diseases are influenced by multiple interconnected biological pathways.
CircRNA signals provide insight across these pathways, supporting investigation of the complex biology underlying brain disease.
Many neurological diseases are associated with distinct circRNA expression patterns, provinding insight into both disease-specific biology and shared molecular pathways.
This biological diversity creates opportunities to investigate a broad range of neurological and neurpsychiatric disorders.
By providing insight into the biological pathways shared across neurological diseases, circRNA creates new opportunities for neuroscience research.
Potential applications include biomarker discovery, disease characterization, patient strateification, and therapeutic development.